Acknowledgements
We thank the staff members of the Large-scale Protein Preparation System at the National Facility for Protein Science in Shanghai (NFPS), Shanghai Advanced Research Institute, Chinese Academy of Science, China, for providing technical support and assistance in data collection and analysis. We thank the Institutional Technology Service Center of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, for technical assistance in mass spectrometry experiments and analysis.
Funding
This work was supported by the following grants: the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0830200, XDB1260301), National Natural Science Foundation of China (T2225002 and 82273855 to M.Z., 82474143 to S.Z., 82404513 D.T.), National Key Research and Development Program of China (2023YFC2305904 and 2022YFC3400504 to M.Z.), the Youth Innovation Promotion Association CAS (2023296 to S.Z.), Young Elite Scientists Sponsorship Program by CAST (2023QNRC001 to S.Z.), Postdoctoral Fellowship Program of CPSF (GZC20232846 to D.T.), China Postdoctoral Science Foundation (2024M763419 to D.T.).
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Zhou, J., Ma, X., Jiang, B. et al. Omaveloxolone functions as a molecular crowbar-like degrader of STING to alleviate aging-related inflammation. Nat Commun (2026). https://doi.org/10.1038/s41467-026-77760-1
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DOI: https://doi.org/10.1038/s41467-026-77760-1
