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Cytotoxic CD4+ T cells support age-associated myelopoiesis

September 19, 2026
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Nature Aging (2026) Cite this article

Aging is associated with myeloid-biased hematopoiesis, which leads to the establishment of a pro-inflammatory microenvironment. We discovered that cytotoxic CD4+ T cells foster this process via the CCL5–CCR5 axis and found that the clinically approved CCR5 antagonist maraviroc can rebalance immunity in aged mice.

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Fig. 1: Targeting the CCL5–CCR5 axis ameliorates age-associated hematopoietic dysfunction associated with cytotoxic CD4+ T cell accumulation.

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References

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This is a summary of: Gabandé-Rodríguez, E. et al. Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling. Nat. Aging https://doi.org/10.1038/s43587-026-01209-9 (2026).

E.G.-R., G.S.-H. and M.M. used ChatGPT to help prepare their contribution to this Research Briefing.

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Cytotoxic CD4+ T cells support age-associated myelopoiesis. Nat Aging (2026). https://doi.org/10.1038/s43587-026-01241-9

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  • DOI: https://doi.org/10.1038/s43587-026-01241-9

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