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X inactivation
Nature Aging (2025)Cite this article
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Most genes on the inactive X chromosome are repressed throughout life, but there are exceptions. Hoelzl and colleagues map genes that escape repression in multiple organs over the lifespan of mice and show an increased rate of escape during aging, as well as association with human disease.
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Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology ETH Hoenggerberg, Zurich, Switzerland
Anton Wutz
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Correspondence to Anton Wutz.
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Wutz, A. X inactivation shows frail ends when mice age. Nat Aging (2025). https://doi.org/10.1038/s43587-025-00874-6
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DOI: https://doi.org/10.1038/s43587-025-00874-6