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Intrinsic capacity
Nature Aging (2025)Cite this article
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Intrinsic capacity, the composite of an individual’s physical and mental capacities, is fundamental to healthy aging. Fuentealba and colleagues use DNA methylation data to develop an epigenetic predictor of intrinsic capacity and pinpoint immune system dysfunction as a key driver of intrinsic capacity decline.
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Acknowledgements
The authors were supported by grants from the National Natural Science Foundation of China (82171584 and 72374180), Research Center of Prevention and Treatment of Senescence Syndrome, School of Medicine Zhejiang University (2022010002), ‘Pioneer’ and ‘Leading Goose’ R&D Programs of Zhejiang Province (2025C02104 and 2023C03163), Zhejiang Key Laboratory of Intelligent Preventive Medicine (2020E10004) and Zhejiang University School of Public Health Interdisciplinary Research Innovation Team Development Project. The funders had no role in the writing of the article or the decision to submit the article for publication.
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Jia, X., Liu, Z. Developing a blood-based epigenetic clock for intrinsic capacity. Nat Aging (2025). https://doi.org/10.1038/s43587-025-00899-x
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DOI: https://doi.org/10.1038/s43587-025-00899-x