Clonal biases dictate availability of colonic cancer driver mutations for transformation

All code for reproducing the analyses in this paper can be found at the GitLab repository https://gitlab.com/davidtourigny/crypt-clone-dynamics.

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Authors and Affiliations

1. CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

   Nefeli Skoufou-Papoutsaki, Richard Kemp, Sam Adler, Anne-Claire Girard, Shenay Mehmed, Filipe C. Lourenço, Elisa B. Moutin & Douglas J. Winton

2. Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK

   Nefeli Skoufou-Papoutsaki & Douglas J. Winton

3. Pathology and Data Analytics, Leeds Institute of Medical Research, University of Leeds School of Medicine, University of Leeds, Leeds, UK

   Kate Marks

4. Department of Oncology, University of Cambridge, Cambridge, UK

   Rogier Ten Hoopen

5. MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK

   Edward Morrissey

6. School of Mathematics, University of Birmingham, Birmingham, UK

   David S. Tourigny

Contributions

N.S.P.: conceptualisation, formal analysis, funding acquisition, investigation, methodology, validation, visualisation, writing-original draft and review/editing. R.K.: conceptualisation, methodology, data curation, formal analysis, software, visualisation. S.A.: investigation, methodology, validation. K.M.: resources, formal analysis. A.C.G.: project administration, data curation. S.M.: investigation. F.L.: supervision. E.B.M.: writing-review and editing. R.T.H.: resources, project administration. E.M.: software. D.J.W.: conceptualisation, funding acquisition, supervision, writing-original draft and review/editing. D.S.T.: methodology, software, visualisation, writing-original draft and review/editing.

Corresponding authors

Correspondence to Douglas J. Winton or David S. Tourigny.

Competing interests

The authors declare no competing interests.

Peer review information

Nature Communications thanks Hugo Snippert and the other anonymous reviewer for their contribution to the peer review of this work. A peer review file is available.

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