Date

May 15, 2025

Source

Nature

Categories

Ancient viruses sustain mammalian reproduction
  • News & Views
  • Published:

Reproductive aging

Nature Aging volume 5pages 728–730 (2025)Cite this article

Subjects

Wood and colleagues reveal that two retrotransposon-derived capsid genes are essential for preserving male and female fertility in mice. Their discovery suggests that ancient viral proteins mediate cell–cell communication in the gonads, which offers a striking example of viral gene domestication in reproductive biology.

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Fig. 1: Cell type-specific expression of PNMA1 and PNMA4 in reproductive tissues and potential intercellular communication via viral capsids.

References

  1. Wood, T. W. P. et al. Nat. Aging https://doi.org/10.1038/s43587-025-00852-y (2025).

    Article  PubMed  Google Scholar 

  2. Dalmau, J. et al. Brain 122, 27–39 (1999).

    Article  PubMed  Google Scholar 

  3. Schüller, M., Jenne, D. & Voltz, R. J. Neuroimmunol. 169, 172–176 (2005).

    Article  PubMed  Google Scholar 

  4. Bejarano, I., Rodríguez, A. B. & Pariente, J. A. Front. Cell Dev. Biol. 6, 65 (2018).

    Article  PubMed  Google Scholar 

  5. Tan, K. O. et al. J. Biol. Chem. 276, 2802–2807 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Kaur, S. & Kurokawa, M. Int. J. Mol. Sci. 24, 1345 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Laureau, R. et al. Dev. Cell 56, 22–35 (2021).

    Article  CAS  PubMed  Google Scholar 

  8. Xu, J. et al. Cell 187, 831–845 (2024).

    Article  CAS  PubMed  Google Scholar 

  9. Gauthier, J., Drezen, J.-M. & Herniou, E. A. Parasitology 145, 713–723 (2018).

    Article  PubMed  Google Scholar 

  10. Lavialle, C. et al. Phil. Trans. R. Soc. Lond. B 368, 20120507 (2013).

    Article  Google Scholar 

  11. Ashley, J. et al. Cell 172, 262–274 (2018).

    Article  CAS  PubMed  Google Scholar 

  12. Pastuzyn, E. D. et al. Cell 172, 275–288 (2018).

    Article  CAS  PubMed  Google Scholar 

  13. Nakamura, S., Kobayashi, K., Nishimura, T., Higashijima, S. & Tanaka, M. Science 328, 1561–1563 (2010).

    Article  CAS  PubMed  Google Scholar 

  14. Meng, L. et al. Cell Prolif. 56, e13371 (2023).

    Article  PubMed  Google Scholar 

  15. World Health Organization. Infertility Prevalence Estimates (WHO, 2023).

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Acknowledgements

The authors thank M. McManus for discussions and edits.

Author information

Authors and Affiliations

  1. Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Francisco, San Francisco, CA, USA

    Caroline A. Doherty & Diana J. Laird

  2. The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA

    Caroline A. Doherty & Diana J. Laird

  3. Center for Reproductive Sciences and Department of Obstetrics, Gynecology and Reproductive Science, Institute for Regeneration Medicine, Bakar Aging Research Institute, University of California San Francisco, San Francisco, CA, USA

    Diana J. Laird

Corresponding author

Correspondence to Diana J. Laird.

Ethics declarations

Competing interests

D.J.L. is a scientific advisor to Vitra, Inc.

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Doherty, C.A., Laird, D.J. Ancient viruses sustain mammalian reproduction. Nat Aging 5, 728–730 (2025). https://doi.org/10.1038/s43587-025-00867-5

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  • DOI: https://doi.org/10.1038/s43587-025-00867-5

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