New white paper from second Roundtable explores AI, biomarkers and standardization – and sets a course for credibility in a maturing sector.
Organized by the International Institute of Longevity (IIOL) and held at the Buck Institute in California in December 2024, the second Roundtable of Longevity Clinics built on the success of its inaugural gathering the previous year. The event brought together clinicians, scientists and operators from across the longevity ecosystem for two days of structured discussion, collaboration and data sharing – the resulting white paper now serves as both a record of those proceedings and a quietly determined call to action.
Produced by IIOL, the 53-page document shifts emphasis from the foundational definitions and regulatory context of the first paper to a more operational focus on what longevity clinics are actually doing – and how they might do it better. There is a subtle but notable reframing here: from a call for legitimacy to a collective effort to improve care quality, track outcomes and offer more reproducible, scientifically grounded services. (Read more thoughts and opinions in our Longevity Clinics Survey 2025.)
Longevity.Technology: As the longevity clinic ecosystem expands, what this new IIOL white paper makes plain is that credibility is now the currency of progress. Amid a marketplace still wrestling with hype, heterogeneity and scientific overreach, the shift from exploratory positioning to structured best practices marks a maturing moment for the sector. Calls for harmonized standards, evidence-led interventions and regulated frameworks are no longer aspirational – they have become essential. The white paper’s emphasis on reproducibility, AI-integrated diagnostics and longitudinal outcome tracking suggests the field is ready to move beyond promise into proof, and if longevity clinics are to scale beyond the early adopter elite, frameworks that deliver both clinical rigor and operational reproducibility will be non-negotiable. Investors and health systems alike will be watching for signals of consistency, safety and cost-effectiveness – and this paper gives the clearest articulation yet of what that could look like.
It is also interesting to note that this year’s white paper addresses – at last and with some urgency – the persistent gap in women’s health within the longevity paradigm. While the science of ovarian aging is foundational to female healthspan, it has often been overlooked in favor of broader (and often male-skewed) biomarker development. Recognition of this disparity, and calls for more targeted research and intervention, are long overdue. If longevity medicine is to evolve as a truly universal discipline, it must be inclusive not only in access but in its underlying evidence base. Addressing this imbalance won’t just expand the field’s relevance – it may unlock entirely new therapeutic pathways.
Biomarkers, platforms and clinical decision-making
Biological age biomarkers remain central to the ambitions of the sector. The paper offers a nuanced view of the state of play, citing a growing preference for next-generation epigenetic clocks such as GrimAgeV2 and DunedinPACE, as well as multi-omics approaches that allow for organ-specific aging insights. What emerges is not a race to declare a single definitive metric, but a broader shift toward composite, explainable tools that can inform individualized care strategies.
Here, too, the role of AI is prominent – not just as a marketing term but as an analytical layer applied to increasingly complex datasets from wearables, blood panels, imaging and longitudinal genomic profiling. Clinics are beginning to use AI to refine both diagnostics and interventions, and several are integrating digital twins, allowing them to simulate patient trajectories and model outcomes over time.
This technological sophistication, however, remains unevenly distributed – and the paper is pragmatic about this. While many clinics report integration of AI and digital tools, full interoperability with electronic medical records is still limited. The desire for shared data standards and collaborative analysis is evident; the mechanism for achieving it is, as yet, unresolved.
Training, trust and professional identity
The paper touches importantly on the question of clinical training; with few formal education routes currently available, most practitioners are drawing on adjacent specialisms – functional medicine, preventive health and lifestyle and genomic counseling. The IIOL proposes a framework for internationally recognized training and certification, positioning it not as a constraint but as a necessary next step in professionalizing the field.
This ambition extends to how clinics describe themselves and their clients. Moving away from the language of illness and ‘patients’, some now refer to ‘members’, ‘participants’ or ‘guests’ – reflecting a proactive rather than reactive approach to care. Still, semantics alone won’t safeguard reputation; as the paper notes, longevity clinics must guard against pseudoscience if they wish to avoid regulatory skepticism and public mistrust.
A quiet pivot toward maturity
Although the paper avoids polemic, its underlying message is clear: longevity medicine is at a pivotal stage. The opportunity is considerable – not just commercially, but in terms of reshaping preventive care – yet it comes with responsibilities that the paper does not shy away from naming. Data integrity, evidence thresholds and ethical transparency are not optional extras; they are the scaffolding on which mainstream integration may ultimately rest.
If longevity medicine is to move from the margins to the mainstream, its operators must act not only as innovators but as system-builders. This white paper suggests many are ready to do just that.
Read the white paper In search of best practices for Longevity Clinics below or download it HERE.
Save the date! The 3rd edition of the Longevity Clinics Roundtable will be at the Buck Institute in Novato, California, 6th–8th December 2025. Find out more information and book your ticket HERE – early bird offer until 30th June.
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