Medical Name(s)

Dutasteride

Alternate Name(s)

Avodart

Dutasteride lowers dihydrotestosterone (DHT) by inhibiting both type I and II 5-alpha reductase isoenzymes. Clinically, it helps reduce an enlarged prostate and off-label combats androgenic alopecia.

Compared to Finasteride, it may cause a deeper reduction in DHT, potentially translating to stronger hair and prostate benefits. However, its potency also increases the risk of sexual side effects. Medical supervision is key for older men exploring it.

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Niacinamide (nicotinamide) boosts intracellular NAD⁺, supports DNA repair, and exhibits anti‑inflammatory effects in keratinocytes. Topical 4 % solutions improve hair fullness and reduce scalp irritation.

Spironolactone

Spironolactone is a mineralocorticoid receptor antagonist with anti‑androgen properties. Oral doses 50–200 mg/day lower systemic and follicular DHT, making it a mainstay for female‑pattern hair loss.