Dihydrotestosterone
5α-dihydrotestosterone; androstanolone
Dihydrotestosterone is the 5α-reduced metabolite of testosterone generated by the enzymes SRD5A1/2. It binds the androgen receptor with ~3 × higher affinity than testosterone, shortening the anagen phase and miniaturising susceptible follicles in androgenetic alopecia (AGA). Systemically, DHT influences prostate growth and sexual differentiation, making it a central target for 5-α-reductase inhibitors used in both dermatology and urology.
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